Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 10, 2009Circulation Research

Perturbation of Notch signaling in embryonic cardiomyocytes causes developmental defects and perinatal lethality, whereas augmentation of Notch1 post-myocardial infarction in adults increases survival, improves cardiac function, and minimizes fibrosis.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does modulation of Notch signaling affect heart morphogenesis in embryos and cardiac repair after myocardial infarction in adults?

Population

Embryonic and adult mammalian heart models (adult models subjected to myocardial infarction)

Design

Preclinical

Authors

PKPaschalis KratsiosUniversity of ChicagoCCCatarina CatelaUniversity of ChicagoESEkaterina SalimovaAustralian Regenerative Medicine Institute

Discussion

Loading...

Member takes

Overview

Augmenting Notch1 post-MI may enhance adult repair; leaves open clinical translation from animal models.

Structured PICO

Does modulation of Notch signaling affect heart morphogenesis in embryos and cardiac repair after myocardial infarction in adults?

P
Population
Embryonic and adult mammalian heart models (adult models subjected to myocardial infarction)
I
Intervention
Conditional overexpression of Notch1 intracellular domain (NICD1) or selective silencing of Notch signaling (embryonic); cardiomyocyte-specific Notch1 transgene expression or intramyocardial delivery of a Notch1 pseudoligand (adult)
O
Outcome
Developmental defects and perinatal lethality (embryonic); survival rate, cardiac functional performance, and fibrosis (adult)surrogate

Notch signaling is strictly required for embryonic heart morphogenesis, and its targeted activation in the adult heart post-myocardial infarction can therapeutically improve survival and cardiac function.

Cite This Study

Kratsios et al. (2009) studied this question.

synapsesocial.com/papers/6a8c89ef741e0864cb6c1949https://doi.org/10.1161/circresaha.109.203034
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of Notch signaling in the mammalian heart2013 · 52 citations
  2. 2The Notch pathway controls fibrotic and regenerative repair in the adult heart2012 · 157 citations
  3. 3Notch Signaling in Ischemic Damage and Fibrosis: Evidence and Clues from the Heart2017 · 48 citations
  4. 4Epigenetic Modification at Notch Responsive Promoters Blunts Efficacy of Inducing Notch Pathway Reactivation After Myocardial Infarction2014 · 75 citations
  5. 5Notch signal pathway - therapeutic target for regulation of reparative processes in the heart2018 · 6 citations