Key result
Notch activation improves post-injury cardiac function in animal models by promoting regeneration and reducing apoptosis.
This review highlights the central regulatory role of the Notch signaling pathway in cardiac development, congenital heart disease, and myocardial regeneration, suggesting its potential as a therapeutic target.
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Should not yet change post-MI care; extends preclinical rationale for Notch as regenerative target in HF.
This review summarizes the critical role of the Notch signaling pathway in cardiac development, congenital heart disease, and myocardial regeneration. The Notch signaling pathway exerts a profound impact on cardiac health and disease progression by finely regulating the fate determination of cardiac progenitor cells, cardiac morphogenesis, and the proliferation and apoptosis of cardiomyocytes. The article also explores the research progress of the Notch signaling pathway as a potential therapeutic target and looks forward to future research directions.
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Liu et al. (2026) conducted a review in Patients and animal models with congenital heart disease, myocardial infarction, and myocardial injury involving Notch signaling pathway abnormalities. Activation or inhibition of Notch signaling pathway was evaluated on Improvement in cardiac function and reduction in myocardial apoptosis or remodeling through Notch signaling modulation. Activation of the Notch signaling pathway promotes myocardial regeneration and reduces apoptosis, improving cardiac function after injury in animal models.
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