Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 7, 2026Frontiers in Bioengineering and BiotechnologyOpen Access

Notch activation improves post-injury cardiac function in animal models by promoting regeneration and reducing apoptosis.

View Full Paper
Ask AI
Bookmark
Share

Design

Review

Key result

Activation of the Notch signaling pathway promotes myocardial regeneration and reduces apoptosis, improving cardiac function after injury in animal models.

Authors

YLYaping LiuXWXiaoxiao WangXTXingyue Tao

Discussion

Loading...

Member takes

Overview

Should not yet change post-MI care; extends preclinical rationale for Notch as regenerative target in HF.

Key Points

  • The review aims to highlight the significance of the Notch signaling pathway in heart development and disease.
  • Comprehensive literature review on Notch signaling in cardiac contexts.
  • Analysis of its impact on cardiac progenitor cell fate and cardiomyocyte behavior.
  • Discussion on therapeutic implications and future research directions.
  • Notch signaling is crucial for proper cardiac development and regeneration.
  • It regulates cardiac progenitor cell fate and influences cardiomyocyte proliferation and apoptosis.
  • Identifying Notch as a therapeutic target could advance treatments for congenital heart disease.

PICO

P
Population
Patients and animal models with congenital heart disease, myocardial infarction, and myocardial injury involving Notch signaling pathway abnormalities
I
Intervention / Comparator
Activation or inhibition of Notch signaling pathway
O
Primary Outcome
Improvement in cardiac function and reduction in myocardial apoptosis or remodeling through Notch signaling modulation

This review highlights the central regulatory role of the Notch signaling pathway in cardiac development, congenital heart disease, and myocardial regeneration, suggesting its potential as a therapeutic target.

Limitations

  • No clinical trial data reported, only preclinical and mechanistic studies included.
  • Lack of quantitative clinical efficacy data and numerical outcome measures.
  • Review summarizes available evidence without new experimental results.

Cite This Study

Liu et al. (2026) conducted a review in Patients and animal models with congenital heart disease, myocardial infarction, and myocardial injury involving Notch signaling pathway abnormalities. Activation or inhibition of Notch signaling pathway was evaluated on Improvement in cardiac function and reduction in myocardial apoptosis or remodeling through Notch signaling modulation. Activation of the Notch signaling pathway promotes myocardial regeneration and reduces apoptosis, improving cardiac function after injury in animal models.

synapsesocial.com/papers/69abc0b85af8044f7a4e954fhttps://doi.org/10.3389/fbioe.2025.1731605
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of Notch signaling in the mammalian heart2013 · 52 citations
  2. 2Notch signal pathway - therapeutic target for regulation of reparative processes in the heart2018 · 6 citations
  3. 3Notch Signaling in Ischemic Damage and Fibrosis: Evidence and Clues from the Heart2017 · 48 citations
  4. 4The Notch pathway controls fibrotic and regenerative repair in the adult heart2012 · 157 citations
  5. 5Distinct Roles for Cell-Autonomous Notch Signaling in Cardiomyocytes of the Embryonic and Adult Heart2009 · 127 citations