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April 5, 2017Frontiers in PharmacologyOpen Access

Notch signaling participates in the protective response to cardiac ischemia and modulates pro-fibrotic myofibroblast differentiation, suggesting it as a potential target for cardiotropic therapies.

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SNSilvia NistriCSChiara SassoliDBDanièle Bani

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Overview

Notch modulation may influence post-ischemic repair; leaves open whether targeting improves clinical outcomes.

Key Points

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Cite This Study

Nistri et al. (2017) studied this question.

synapsesocial.com/papers/6a79573f756812e39588ff05https://doi.org/10.3389/fphar.2017.00187
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of Notch signaling in the mammalian heart2013 · 52 citations
  2. 2The Notch pathway controls fibrotic and regenerative repair in the adult heart2012 · 157 citations
  3. 3Notch signal pathway - therapeutic target for regulation of reparative processes in the heart2018 · 6 citations
  4. 4Distinct Roles for Cell-Autonomous Notch Signaling in Cardiomyocytes of the Embryonic and Adult Heart2009 · 127 citations
  5. 5Notch signaling pathway and heart development, congenital heart disease, and myocardial regeneration2026 · 2 citations