Key result
Targeting Notch signaling shows promise for post-MI repair by promoting angiogenesis, reducing apoptosis, and inhibiting fibrosis.
Why the study?
Limited regenerative capacity and excessive fibrosis after myocardial infarction highlight the need for effective therapeutic strategies.
Does targeting the Notch signaling pathway improve cardiac repair after myocardial infarction?
Design
Review
Authors
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Hypothesis-generating for Notch modulation post-MI; randomized trials needed before clinical consideration.
Does targeting the Notch signaling pathway improve cardiac repair after myocardial infarction?
Modulating the Notch signaling pathway offers a promising therapeutic avenue for cardiac repair post-MI by promoting angiogenesis and reducing fibrosis, though clinical translation remains challenging.
Zhang et al. (2025) conducted a review in Myocardial infarction. Notch signaling pathway modulation was evaluated. Targeting the Notch signaling pathway offers a promising therapeutic strategy for cardiac repair post-myocardial infarction by promoting angiogenesis, reducing apoptosis, and inhibiting fibrosis.
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