Key result
Modulation of the Notch pathway represents a potential therapeutic target to limit pathological ventricular remodelling and the associated deterioration of cardiac performance in heart failure.
Modulation of the Notch pathway represents a potential novel therapeutic avenue to limit pathological ventricular remodeling and heart failure progression.
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Notch modulation merits clinical investigation in heart failure; leaves open whether it limits remodeling in patients.
Pathological ventricle remodelling, which follows a cardiac insult, causes heart failure. Despite the existence of multiple pharmaceutical approaches, heart failure is one of the leading causes of death worldwide and there is an urgent need to explore new therapeutic avenues. The Notch pathway is an evolutionary conserved fundamental pathway that regulates cell fate during development as well as throughout postnatal life in self-renewing tissues. In the myocardium, Notch signalling is involved in the modulation of cardiomyocytes survival, cardiac stem cells differentiation, and angiogenesis which are factors known to determine the extent of pathological cardiac remodelling. Modulation of the Notch pathway could become a tool to limit ventricle remodelling and the associated inexorable deterioration of cardiac performance.
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Ferrari et al. (2014) conducted a review in Heart failure and myocardial remodelling. Notch pathway modulation was evaluated. Modulation of the Notch pathway represents a potential therapeutic target to limit pathological ventricular remodelling and the associated deterioration of cardiac performance in heart failure.
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