Why the study?
Acute myocardial infarction severely affects public health, and understanding the role of the Notch signaling pathway in post-infarction repair and cardiac regenerative medicine can provide a reference for treatment.
This review highlights the therapeutic potential of targeting the Notch signaling pathway in cardiac regenerative medicine and myocardial infarction repair.
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Therapeutic Notch modulation post-MI remains investigational; review extends mechanistic insights but leaves clinical adoption open.
Acute myocardial infarction is myocardial necrosis caused by acute and persistent ischemia and hypoxia in the coronary artery and severely affects public health. Recently, stem cell research has presented transformational developments in treating myocardial infarction. The Notch signaling pathway plays a crucial role in the post-myocardial infarction repair process and cardiac regenerative medicine. Additionally, the Notch signaling pathway can be involved in regulating the inflammatory response, myocardial fibrosis, oxidative stress, cardiomyocyte apoptosis, and cardiomyocyte regeneration after myocardial infarction. Moreover, the Notch signaling pathway is applied in cardiac tissue engineering. This review mainly elaborates on the research on the Notch signaling pathway in repairing myocardial infarction and cardiac regenerative medicine, aiming to provide a reference for treating acute myocardial infarction.
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Cai et al. (2025) studied this question.
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