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December 12, 2013Brazilian Journal of Medical and Biological ResearchOpen Access

Notch signaling is critical in mammalian cardiogenesis and can repair myocardial injury by promoting myocardial regeneration, protecting ischemic myocardium, inducing angiogenesis, and negatively regulating cardiac fibroblast-myofibroblast transformation.

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Population

Mammalian heart models of cardiogenesis and myocardial injury

Design

Review

Authors

XZXueliang ZhouJLJichun Liu

Discussion

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Overview

Supports preclinical rationale for Notch-targeted cardiac repair; leaves open clinical translation without prospective trials.

Structured PICO

P
Population
Mammalian heart models of cardiogenesis and myocardial injury
I
Intervention
Notch signaling pathway modulation

Notch signaling plays a critical role in mammalian cardiogenesis and offers potential therapeutic targets for myocardial injury repair and regeneration.

Cite This Study

Zhou et al. (2013) studied this question.

synapsesocial.com/papers/6a725752f44fa9f079dfdce7https://doi.org/10.1590/1414-431x20133177
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Notch signaling pathway and heart development, congenital heart disease, and myocardial regeneration2026 · 2 citations
  2. 2Notch Signaling in Ischemic Damage and Fibrosis: Evidence and Clues from the Heart2017 · 48 citations
  3. 3Distinct Roles for Cell-Autonomous Notch Signaling in Cardiomyocytes of the Embryonic and Adult Heart2009 · 127 citations
  4. 4Notch signal pathway - therapeutic target for regulation of reparative processes in the heart2018 · 6 citations
  5. 5The Notch pathway controls fibrotic and regenerative repair in the adult heart2012 · 157 citations