Key result
The HOT Study is a randomized trial designed to evaluate three diastolic blood pressure targets and low-dose aspirin on cardiovascular outcomes in an estimated 18,000 hypertensive patients.
Why the study?
Does targeting lower diastolic blood pressure and adding low-dose aspirin reduce cardiovascular morbidity and mortality in hypertensive patients?
Population
At least 18,000 hypertensive men and women aged 50-80 years, multinational (some 20 countries world-wide).
Comparison
Target diastolic blood pressure ≤90 mmHg, ≤85… vs Different diastolic blood pressure targets…
Design
RCT, Randomized to three different therapeutic goals, PROBE design for blood…
Follow-up
2.5 years
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Optimal diastolic BP targets remain uncertain in hypertension; this Level 3 cohort analysis leaves open the ideal threshold pending further data.
RCT (n=18,000)
PROBE and Double-blind
Randomized
Yes
Does targeting lower diastolic blood pressure and adding low-dose aspirin reduce cardiovascular morbidity and mortality in hypertensive patients?
The HOT study is designed to determine the optimal target diastolic blood pressure and the effect of low-dose aspirin on cardiovascular outcomes in hypertensive patients.
A 1993 study conducted an RCT in Hypertension (n=18,000). Target diastolic blood pressure (<90, <85, or <80 mmHg) and Acetylsalicylic acid vs. Placebo (for aspirin) was evaluated on Cardiovascular morbidity and mortality. The HOT Study is a randomized trial designed to evaluate three diastolic blood pressure targets and low-dose aspirin on cardiovascular outcomes in an estimated 18,000 hypertensive patients.
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