January 1, 1995Blood Pressure
The Hypertension Optimal Treatment (HOT) Study: 12-month Data on Blood Pressure and Tolerability. With Special Reference to Age and Gender
Why the study?
What are the achieved blood pressures and tolerability at 12 months for different target diastolic blood pressure levels in hypertensive patients?
Population
19,193 hypertensive patients, including 6,113 elderly and 13,080 younger patients, from 26 countries.
Comparison
Target diastolic blood pressure ≤85 mmHg or ≤80… vs Target diastolic blood pressure ≤90 mmHg and/or…
Design
RCT, randomized, placebo-controlled (for aspirin arm)
Follow-up
12 months
Authors
Discussion
Loading...
Member takes
Implication
Intensive diastolic BP targets are achievable; extends feasibility data for lower goals in hypertension RCTs.
Structured PICO
What are the achieved blood pressures and tolerability at 12 months for different target diastolic blood pressure levels in hypertensive patients?
P
Population
19,193 hypertensive patients, including 6,113 elderly (≥65 years) and 13,080 younger (<65 years) patients, from 26 countries.
I
Intervention
Target diastolic blood pressure ≤85 mmHg or ≤80 mmHg (achieved via stepped care initiated with felodipine 5 mg daily, adding ACE inhibitor, beta-blocker, or diuretic as needed) and/or acetylsalicylic acid 75 mg daily.
C
Comparator
Target diastolic blood pressure ≤90 mmHg and/or placebo.
O
Outcome
Blood pressures achieved and tolerability at 12 months of follow-up (main trial aims for cardiovascular morbidity and mortality).surrogate
This 12-month report from the HOT study demonstrates that intensive diastolic blood pressure targets are achievable and well-tolerated using a felodipine-based stepped-care approach.
Cite This Study
Hansson et al. (1995) studied this question.