The Hypertension Optimal Treatment (HOT) Study: 24-month Data on Blood Pressure and Tolerability
Why the study?
Does intensive diastolic blood pressure lowering and/or low-dose aspirin improve cardiovascular outcomes in hypertensive patients?
Population
18,790 hypertensive patients (n=12,802 aged <65 years; n=5,988 aged ≥65 years) from 26 countries.
Comparison
Target diastolic blood pressure ≤85 or ≤80 mmHg… vs Target diastolic blood pressure ≤90 mmHg and/or…
Design
RCT, randomized, placebo-controlled (for aspirin)
Follow-up
24 months
Authors
Discussion
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Implication
Felodipine-based step-up regimens enable reliable achievement of intensive diastolic targets; extends RCT evidence on long-term control and tolerability in hypertension.
Structured PICO
Does intensive diastolic blood pressure lowering and/or low-dose aspirin improve cardiovascular outcomes in hypertensive patients?
P
Population
18,790 hypertensive patients (n=12,802 aged <65 years; n=5,988 aged ≥65 years) from 26 countries.
I
Intervention
Target diastolic blood pressure ≤85 or ≤80 mmHg (achieved via felodipine 5 mg daily step-up therapy) and/or acetylsalicylic acid 75 mg daily.
C
Comparator
Target diastolic blood pressure ≤90 mmHg and/or placebo.
O
Outcome
Incidence of cardiovascular morbidity and mortality (primary aim of the trial); this report focuses on blood pressure achieved and tolerability at 24 months.surrogate
At 24 months, a felodipine-based step-up antihypertensive regimen successfully achieved target diastolic blood pressures in the majority of patients with good tolerability.
Cite This Study
Hansson et al. (1997) studied this question.