Key result
A reduction in pH from 7.0 to 6.5 induced a 0.4 pCa unit rightward shift in calcium activation in adult dog heart myofilaments, but had no effect in perinatal preparations.
Population
Myofilament preparations of adult and perinatal dog hearts
Comparison
Reduction in pH from 7.0 to 6.5 (acidic pH) vs pH 7.0 and comparison between adult and…
Design
Preclinical
Authors
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Highlights age-specific myofilament pH responses; leaves open human perinatal relevance and mechanisms.
Perinatal dog heart myofilaments are resistant to the desensitizing effects of acidic pH on calcium activation seen in adult hearts, suggesting developmental differences in thin filament regulation.
Solaro et al. (1986) studied this question. Reduction in pH from 7.0 to 6.5 vs. pH 7.0 was evaluated on Calcium activation of myofilament preparations (relation between pCa and myofibrillar adenosine triphosphatase activity). A reduction in pH from 7.0 to 6.5 induced a 0.4 pCa unit rightward shift in calcium activation in adult dog heart myofilaments, but had no effect in perinatal preparations.
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