Movement of apolipoprotein B into the lumen of microsomes from hepatocytes is disrupted in membranes enriched in phosphatidylmonomethylethanolamine.

Rusiñol et al. (1993) studied this question. Monomethylethanolamine vs. Control cells was evaluated on Amount of apoproteins B present in the luminal content subfraction of microsomes. Treatment of rat hepatocytes with monomethylethanolamine decreased the amount of apoprotein B in the microsomal lumen by approximately 50%, impairing its translocation across the endoplasmic reticulum.