Key result
Patients with dilated cardiomyopathy and functional mitral regurgitation had decreased mitral annulus fractional area change (15% vs 28%) and displacement (5 vs 10 mm) versus controls (p<0.001).
Why the study?
Patients with dilated cardiomyopathy and functional mitral regurgitation present altered geometry and dynamics of the mitral annulus, but the relationship between mitral annular dysfunction, regurgitation severity, and left atrial dysfunction needed further assessment using 3D transthoracic echocardiography.
Does mitral annulus and left atrial dysfunction correlate with the severity of functional mitral regurgitation in patients with dilated cardiomyopathy?
Population
56 patients with DCM and FMR and 52 controls
Comparison
Patients with DCM and FMR vs controls
Design
Prospective observational case-control study
Authors
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Impaired mitral annular dynamics may worsen functional mitral regurgitation; leaves open whether annular metrics guide therapy or predict outcomes in dilated cardiomyopathy.
Case-Control (n=108)
Does mitral annulus and left atrial dysfunction correlate with the severity of functional mitral regurgitation in patients with dilated cardiomyopathy?
Absolute Event Rate: 15% vs 28%
p-value: p=<0.001
In patients with dilated cardiomyopathy, mitral annulus contractile dysfunction and left atrial enlargement independently predict the severity of functional mitral regurgitation, providing insights for transcatheter mitral valve procedure selection.
Mihaila et al. (2020) conducted a case-control in Dilated cardiomyopathy and functional mitral regurgitation (n=108). Dilated cardiomyopathy and functional mitral regurgitation vs. Controls was evaluated on Mitral annulus fractional area change (MAFAC) (p=<0.001). Patients with dilated cardiomyopathy and functional mitral regurgitation had decreased mitral annulus fractional area change (15% vs 28%) and displacement (5 vs 10 mm) versus controls (p<0.001).
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