Key result
Bicuspid aortic valve morphology may be a genetically linked marker of an inherited predisposition to calcific stenosis rather than its direct cause.
The presentation of calcific aortic stenosis in identical twins with different valve morphologies suggests bicuspid morphology may be a genetically linked marker rather than the direct cause of calcific stenosis.
A pair of identical twins presented almost simultaneously at age 62 years with calcific aortic stenosis requiring surgery, one with bicuspid and one with tricuspid aortic valve. This suggests that bicuspid morphology may perhaps not be the cause, but may be a genetically linked marker of an inherited predisposition to calcific stenosis.
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Lewis et al. (1990) studied this question. Bicuspid aortic valve morphology may be a genetically linked marker of an inherited predisposition to calcific stenosis rather than its direct cause.
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