Key result
Two monozygotic twin brothers presented simultaneously with severe dysfunction of bicuspid aortic valves, highlighting a potential link with apolipoprotein E alleles.
Case Report (n=2)
This case report highlights the simultaneous presentation of severe bicuspid aortic valve dysfunction in monozygotic twins, raising questions about the genetic role of apolipoprotein E alleles.
Hypothesis-generating for apolipoprotein E in bicuspid aortic valve; larger studies needed before any clinical relevance.
Aortic valve disease is a common valvular heart disease but the underlying pathology that leads to the severe dysfunction of the aortic valve is unclear. There is increasing interest in the role of hypercholesterolaemia in the causation and progression of aortic valve disease. Apolipoprotein E is an essential component of cholesterol and previous studies have reported conflicting results on the association between various apolipoprotein E alleles and aortic valve disease. We report two interesting cases of severe dysfunction of bicuspid aortic valves in twin brothers who presented to us at the same time.
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Saravanan et al. (2009) conducted a case report in Severe dysfunction of bicuspid aortic valves (n=2). Apolipoprotein E alleles was evaluated. Two monozygotic twin brothers presented simultaneously with severe dysfunction of bicuspid aortic valves, highlighting a potential link with apolipoprotein E alleles.
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