Key result
Myocardial expression of CRP and TNF-alpha mRNA was present in patients with dilated cardiomyopathy but not in controls, and correlated negatively with systolic function.
Why the study?
Does myocardial expression of CRP and TNF-alpha correlate with clinical severity in patients with dilated cardiomyopathy?
Population
57 subjects undergoing right ventricular endomyocardial biopsy
Design
Case-control
Authors
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Myocardial CRP/TNF-α co-expression may mark DCM inflammation; leaves open whether targeting alters progression or outcomes.
Case-Control (n=57)
Does myocardial expression of CRP and TNF-alpha correlate with clinical severity in patients with dilated cardiomyopathy?
Myocardial co-expression of CRP and TNF-alpha is elevated in dilated cardiomyopathy, correlates with disease severity, and is attenuated by standard heart failure therapies (spironolactone plus ACEI/ARB).
Satoh et al. (2005) conducted a case-control in Dilated Cardiomyopathy (n=57). Dilated cardiomyopathy vs. Controls was evaluated on Myocardial expression of CRP and TNF-alpha mRNA. Myocardial expression of CRP and TNF-alpha mRNA was present in patients with dilated cardiomyopathy but not in controls, and correlated negatively with systolic function.
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