Key result
Administration of clonidine decreased plasma renin activity, arterial pressure, and heart rate, and blocked the renin secretory and blood pressure responses to carotid occlusion in anaesthetized dogs.
Why the study?
Does clonidine reduce plasma renin activity and block sympathetic reflexes during carotid occlusion in anaesthetized dogs?
Population
Anaesthetized dogs in which changes in renal perfusion pressure were prevented
Design
Preclinical
Authors
Loading...
Supports central sympatholytic renin control; leaves open translation to human hypertension management.
Does clonidine reduce plasma renin activity and block sympathetic reflexes during carotid occlusion in anaesthetized dogs?
Clonidine suppresses renin secretion by decreasing sympathetic activity, effectively blocking the renin and blood pressure responses to carotid occlusion in an animal model.
Reid et al. (1976) studied this question. Carotid occlusion and clonidine was evaluated on Plasma renin activity, arterial pressure, and heart rate. Administration of clonidine decreased plasma renin activity, arterial pressure, and heart rate, and blocked the renin secretory and blood pressure responses to carotid occlusion in anaesthetized dogs.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: