Population
Morphine, chloralose-urethane anesthetized dogs
Comparison
Infusion of clonidine into the vertebral artery… vs Pre-clonidine baseline responses
Design
Preclinical
Authors
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Hypothesis-generating for central clonidine actions on reflexes; leaves open translation to human hypertension management.
Clonidine exerts central actions that facilitate the chemoreceptor reflex and inhibit the carotid occlusion reflex, contributing to hypotension.
E. Harper Gillespie (1948) studied this question.
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