Key result
Intravenous angiotensin II infusion in rhesus monkeys significantly increased systemic arterial pressure and total peripheral resistance, and potentiated pressor responses to environmental stress.
Why the study?
Does intravenous angiotensin II alter systemic and regional hemodynamics and potentiate stress responses in unanesthetized rhesus monkeys?
Population
15 supine unanesthetized rhesus monkeys
Comparison
Intravenous angiotensin II infusion vs Intravenous saline infusion
Design
Preclinical
Follow-up
26 to 30 days
Authors
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Supports angiotensin II investigation in stress-related responses; leaves open human clinical translation.
Does intravenous angiotensin II alter systemic and regional hemodynamics and potentiate stress responses in unanesthetized rhesus monkeys?
In unanesthetized monkeys, angiotensin II reduces renal and splanchnic blood flow, and chronic subpressor doses potentiate sympathetic pressor responses to stress.
Forsyth et al. (1971) studied Normal and Environmentally Stressed Monkeys (n=15). Angiotensin II vs. Saline / noninfused monkeys was evaluated on Systemic arterial pressure, total peripheral resistance, and regional blood flow. Intravenous angiotensin II infusion in rhesus monkeys significantly increased systemic arterial pressure and total peripheral resistance, and potentiated pressor responses to environmental stress.
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