March 1, 2004Pacing and Clinical Electrophysiology
QRS Duration and Shortening to Predict Clinical Response to Cardiac Resynchronization Therapy in Patients with End‐Stage Heart Failure
Key result
Baseline QRS duration did not predict clinical response to CRT (179±30 ms in responders vs 171±32 ms in nonresponders, NS), and individual QRS shortening varied highly.
Why the study?
Does QRS duration at baseline or its reduction after CRT predict clinical response in patients with end-stage heart failure?
Population
61 patients with end-stage heart failure (NYHA Class III-IV, LVEF < 35%, QRS > 120 ms with LBBB)
Design
Cohort
Follow-up
6 months
Authors
Discussion
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Implication
Baseline QRS duration should not guide CRT selection; observational data leave QRS shortening's predictive role unresolved.
Study Design
Type
Cohort (n=61)
Structured PICO
Does QRS duration at baseline or its reduction after CRT predict clinical response in patients with end-stage heart failure?
P
Population
61 patients with end-stage heart failure undergoing cardiac resynchronization therapy, evaluated at baseline and after 6 months.
E
Exposure
Cardiac resynchronization therapy (CRT)
O
Outcome
Clinical response (improvement of NYHA Class, 6-minute walking distance and quality of life score) at 6 monthscomposite
Baseline QRS duration and its shortening after CRT do not reliably predict individual clinical response to CRT in patients with end-stage heart failure.
Cite This Study
Molhoek et al. (2004) conducted a cohort in End-Stage Heart Failure (n=61). Baseline QRS duration and QRS shortening was evaluated on Clinical response to CRT (improvement of NYHA Class, 6-minute walking distance and quality of life score). Baseline QRS duration did not predict clinical response to CRT (179±30 ms in responders vs 171±32 ms in nonresponders, NS), and individual QRS shortening varied highly.