Key result
Basal RS-V1 interval ≥45 ms is linked to ~10-fold greater odds of clinical response to CRT.
Why the study?
Approximately 30% of patients with dilated cardiomyopathy and wide QRS with LBBB pattern do not benefit from CRT, and improved predictors of CRT success are needed.
Does the RS-V1 interval on ECG predict clinical response to cardiac resynchronization therapy in patients with dilated cardiomyopathy?
Observational (n=51)
Does the RS-V1 interval on ECG predict clinical response to cardiac resynchronization therapy in patients with dilated cardiomyopathy?
Odds Ratio: 9.8
Absolute Event Rate: 83% vs 33%
p-value: p=0.002
A baseline RS-V1 interval ≥ 45 ms on ECG strongly predicts clinical and echocardiographic response to cardiac resynchronization therapy.
May identify CRT responders via basal RS-V1; hypothesis-generating and requires prospective validation before practice change.
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Mollo et al. (2013) conducted an observational in Dilated cardiomyopathy with classical indication to cardiac resynchronization therapy (n=51). Basal RS-V1 interval ≥ 45 ms vs. Basal RS-V1 interval < 45 ms was evaluated on Clinical response to CRT (LVEF increase ≥5% and NYHA class improvement ≥1) (OR 9.8, p=0.002). A basal RS-V1 interval ≥ 45 ms was independently associated with clinical response to cardiac resynchronization therapy at 3 months (OR 9.8; P=0.002).
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