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Astrocytoma is a common aggressive intracranial tumor and a formidable challenge in clinic. Association of the altered DNA methylation pattern of the promoter CpG islands has been found in many human tumors. OCT4 and SOX2 are essential transcription factors for embryonic development and play key roles in determining the fate of stem cells. In this study, we aimed to investigate the methylation profiles of SOX2 and OCT4 genes in astrocytomas samples of Para state. The methylation status of SOX2 and OCT4 genes was examined by methylation-specific polymerase chain reaction (MS-PCR) in 31 samples. At least in the investigated CpG island of SOX2 and OCT4 genes, we found that both promoters are methylated. Understanding these epigenetic mechanisms can lead to better prognostic tools and new drug targets for tumors of the central nervous system.
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Wallax Augusto Silva Ferreira (2015) studied this question.
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