Key result
Continuous static forces selectively reduced SMA mRNA and protein content in rat cardiac fibroblasts to 55 +/- 9% of controls within 4 hours, mediated through the p38 kinase pathway.
Population
Cultured rat cardiac fibroblasts
Comparison
Magnetically generated perpendicular continuous… vs Control cells without force application, or…
Design
Preclinical
Follow-up
8 hours
Authors
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Does not yet change clinical practice in fibrosis; leaves open p38 targeting in cardiac mechanobiology.
Mechanical force directly inhibits alpha-smooth muscle actin expression in cardiac fibroblasts via the p38 kinase pathway, an effect that is antagonized by angiotensin II.
Wang et al. (2000) studied Cultured rat cardiac fibroblasts. Continuous static forces vs. Controls was evaluated on alpha-smooth muscle actin (SMA) mRNA and protein content. Continuous static forces selectively reduced SMA mRNA and protein content in rat cardiac fibroblasts to 55 +/- 9% of controls within 4 hours, mediated through the p38 kinase pathway.
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