Key result
Circulating angiopoietin-2 correlated with pulmonary permeability and lung injury severity (minimum r=0.34, p<0.001) and predicted ARDS (minimum AUC=0.69, p=0.006).
Population
112 mechanically ventilated critically ill patients (24 with sepsis, 88 without sepsis)
Design
Cohort
Authors
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Angiopoietin-2 may signal endothelial permeability in ALI/ARDS; leaves open its biomarker utility pending prospective validation.
Observational (n=112)
Effect estimate: minimum r = 0.34; minimum AUC = 0.69
p-value: p=<0.001
Circulating angiopoietin-2 is associated with pulmonary permeability edema and the occurrence and severity of ALI/ARDS in mechanically ventilated critically ill patients.
Heijden et al. (2008) conducted an observational in Critically ill patients (septic and non-septic) (n=112). Circulating angiopoietin-2 vs. Low levels / non-sepsis was evaluated on Pulmonary permeability oedema (PLI, EVLW) and occurrence/severity of ALI/ARDS (minimum r = 0.34; minimum AUC = 0.69, p=<0.001). Circulating angiopoietin-2 correlated with pulmonary permeability and lung injury severity (minimum r=0.34, p<0.001) and predicted ARDS (minimum AUC=0.69, p=0.006).
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