Key result
In older adults with heart failure with preserved ejection fraction, having three or more comorbidities was associated with significantly higher IL-6 levels compared to having only one comorbidity (15.2 vs 8.46 pg/ml, p=0.00019).
Why the study?
Heart failure with preserved ejection fraction remains poorly understood despite significant morbidity and mortality, with a hypothesized role for comorbidity-induced systemic inflammation leading to diastolic dysfunction.
Cross-Sectional (n=124)
No
Absolute Event Rate: 15.2% vs 8.46%
p-value: p=0.00019
Systemic inflammation, driven by multiple comorbidities, is significantly correlated with the severity of diastolic dysfunction and heart failure in elderly patients with HFpEF.
May warrant comorbidity-focused interventions in elderly HFpEF; hypothesis-generating and leaves open effects on outcomes.
The treatment of chronic heart failure reached significant progress within the last decades. However, the progress is mainly limited only to patients with reduced ejection fraction, and recently to those with medially reduced ejection fraction, while the heart failure with preserved ejection fraction (HFpEF) remains enigma even beside significant morbidity and mortality. One of suggested hypotheses is, that comorbidities cause systemic inflammation, coronary microvascular dysfunction and oxidative stress, which lead to myocardial fibrosis, stiffness of myocytes and, at the end to diastole dysfunction (DD) and HFpEF. Material and methods: Clinically prospective average study, which included 124 patients, aged above 65 years, out of which 85 patients were in the investigated group, which completed the criteria for existence of HFpEF and present comorbidities, and 39 patients-control group.
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Lidija Veterovska Miljkovic (2022) conducted a cross-sectional in Heart Failure with Preserved Ejection Fraction (HFpEF) (n=124). Multiple comorbidities (3 or more) vs. Single comorbidity was evaluated on IL-6 levels (pg/ml) (p=0.00019). In older adults with heart failure with preserved ejection fraction, having three or more comorbidities was associated with significantly higher IL-6 levels compared to having only one comorbidity (15.2 vs 8.46 pg/ml, p=0.00019).
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