Key result
In anesthetized rats, the hindlimb vasodilator response to acetylcholine is mediated by an initial L-NAME-resistant phase involving K(Ca) channels and a secondary sustained phase mediated by NO.
Population
Anesthetized rats
Comparison
Acetylcholine injections with various pathway… vs Responses without specific inhibitors or to…
Design
Preclinical
Authors
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Animal findings delineate dual ACh vasodilator phases; leaves open translation to human endothelial therapies.
Acetylcholine-induced vasodilation in the rat hindlimb involves both an initial nitric oxide-independent phase mediated by calcium-activated potassium channels and a sustained nitric oxide-dependent phase.
Dabisch et al. (2007) studied this question. Acetylcholine was evaluated on Systemic arterial pressure and hindlimb vascular resistance. In anesthetized rats, the hindlimb vasodilator response to acetylcholine is mediated by an initial L-NAME-resistant phase involving K(Ca) channels and a secondary sustained phase mediated by NO.
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