Key result
Angiotensin II stimulated the production of mRNA for renin system components and growth-related factors in isolated rat hepatic nuclei, with maximal stimulation at 10^-9 mol/l.
The study provides evidence for a functional intracrine renin system where intracellular Angiotensin II regulates gene transcription via nuclear AT1 receptors.
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Nuclear All effects on hepatic gene expression remain unproven in vivo; leaves open modulation by endocrine renin changes.
Eggena et al. (1996) studied this question. Angiotensin II was evaluated on Specific messenger RNAs (mRNA) for renin system components and growth-related factors. Angiotensin II stimulated the production of mRNA for renin system components and growth-related factors in isolated rat hepatic nuclei, with maximal stimulation at 10^-9 mol/l.
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