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August 2, 2026Open Access

Characterizing the molecular and cellular biology of healthy adult human spinal cord

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Authors

XWXindi Wang

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Implication

Characterizes healthy spinal cord biology, examining sex, age, and anatomical level influences.

Key Points

  • This research aims to establish a baseline understanding of the healthy human spinal cord's molecular and cellular characteristics.
  • Analyzed 249 bulk RNA-sequencing and 7 single-nucleus RNA-sequencing samples.
  • Conducted differential gene expression analysis using the DREAM model and gene set enrichment analysis.
  • Performed RNA deconvolution with CIBERSORTx to assess cellular composition.
  • Identified 411 age-associated differentially expressed genes and 101-1,593 level-associated genes, with only 12 sex-associated genes.
  • Found TNF-alpha signaling enrichment in older populations and synaptic transmission pathways in younger populations.
  • Observed increased macrophage abundance with age and varying cell composition by anatomical level.

Cite This Study

Xindi Wang (2026) studied this question.

synapsesocial.com/papers/6a6eeb3b1b0468a7eeab437fhttps://doi.org/10.14288/1.0454186
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences2025 · 1 citations
  2. 2AGING CAUSES STRUCTURAL AND FUNCTIONAL REORGANIZATION OF THE HUMAN SPINAL CORD2025
  3. 3Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord2024 · 19 citations
  4. 4A Single-Nucleus Transcriptomic Atlas of the Mouse Lumbar Spinal Cord: Functional Implications of Non-Coding RNAs2025
  5. 5A Single-Nucleus Transcriptomic Atlas of the Mouse Lumbar Spinal Cord: Functional Implications of Non-Coding RNAs2025