Development and Worsening of Hypertension with Age in Male Wistar Rats as a Physiological Model of Age-Related Hypertension: Correction of Hypertension with Taxifolin

Figure 1. SBP for each age sample (4 months, 10 months, 12 months and 18 months) as a whole. ** p ≤ 0.01 relative to the 4-month age group with pairwise comparison Mann–Whitney U-test. Data are presented as median values (line at median).

Figure 2. Initial SBP when divided into groups—normotensive (SBP less than or equal to 115 mmHg) and hypertensive (SBP above 115 mmHg)—within each age (4, 10, 12 and 18 months). *** p ≤ 0.001 relative to groups with normal blood pressure within each age with pairwise comparison using the Mann–Whitney U-test, # p ≤ 0.05 relative to animals aged 4 months with pairwise comparison using the Mann–Whitney U-test.

Figure 3. Percentage ratio of normotensive and hypertensive animals within the sample of each age (4 months n = 42, 10 months n = 30, 12 months n = 41 and 18 months n = 42). ** p ≤ 0.01 relative to animals aged 4 months according to the Chi square test.

Figure 4. The effect of taxifolin on the SBP of animals of each age (a) 4 months, (b) 10 months, (c) 12 months, (d) 18 months. NORM—normotensive animals (initial SBP is less than or equal to 115 mmHg). HYPER—hypertensive animals (initial SBP is above 115 mmHg). * p ≤ 0.05, ** p ≤ 0.01 relative to day 0 in each group (normotensive or hypertensive) with pairwise comparison using the Mann–Whitney U-test.

Figure 5. Scheme of distribution of animals in the experiment according to the value of SBP and administration of taxifolin.

Figure 6. The process of measuring SBP using a tail cuff in rats.

Figure 7. Screenshot from the PowerLab screen when measuring SBP using a tail cuff.