Key result
Vitamin K1 reverses indirect anticoagulation, whereas Vitamin K3 and its derivatives show no activity.
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A method for the estimation of the activity of compounds like vitamin K using rats treated with an indirect anticoagulant is described. The assay measured the speed of onset and magnitude of the antidotal effect. Under the conditions employed, only vitamin K(1) produced a significant response. Vitamin K(3) and its water-soluble derivatives were inactive. Both the magnitude and the speed of onset of the antidotal effect of vitamin K(1) were found to depend on the extent to which it was in solution. The assay gave results of fair accuracy and reproducibility, which permitted a full statistical analysis and provided an estimate of error.
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Lowenthal et al. (1959) studied Anticoagulant treatment. Vitamin K(1) vs. Vitamin K(3) and its water-soluble derivatives was evaluated on Speed of onset and magnitude of the antidotal effect. Vitamin K(1) produced a significant antidotal response in rats treated with an indirect anticoagulant, whereas Vitamin K(3) and its water-soluble derivatives were inactive.
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