Key result
Beta-blocker use in patients with peripheral arterial disease was associated with a lower heart rate-adjusted augmentation index (P=0.04) but higher augmentation and pulse pressures.
Why the study?
Do β-blockers affect markers of vascular hemodynamics in patients with peripheral arterial disease?
Observational (n=141)
Do β-blockers affect markers of vascular hemodynamics in patients with peripheral arterial disease?
p-value: p=.04
β-blocker use in patients with peripheral arterial disease is associated with altered vascular hemodynamics, including higher augmentation and pulse pressures but lower heart rate-adjusted augmentation index.
Does not support changing beta-blocker use in PAD; leaves open net hemodynamic effects.
Aortic augmentation index (AIx) is a marker of central aortic pressure burden and is modulated by antihypertensive drugs. In patients with peripheral arterial disease (PAD) undergoing antihypertensive treatment, aortic pressures parameters, heart rate-adjusted augmentation index (AIx75), and unadjusted AIx were determined. The (aortic) systolic and diastolic blood pressure did not differ between PAD patients who were taking β-blockers (n=61) and those who were not taking β-blockers (n=80). In patients taking β-blockers, augmentation pressure and pulse pressure were higher than in patients who did not take β-blockers (augmentation pressure, P=.02; pulse pressure, P=.005). AIx75 was lower in PAD patients taking β-blockers than in patients not taking β-blockers (P=.04), while the AIx did not differ between PAD patients taking and not taking β-blockers. The present study demonstrates that β-blockers potentially affect markers of vascular hemodynamics in patients with PAD. Because these markers are surrogates of cardiovascular risk, further studies are warranted to clarify the impact of selective β-blocker treatment on clinical outcome in patients with PAD.
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Schlager et al. (2016) conducted an observational in Peripheral arterial disease (PAD) (n=141). Beta-blockers vs. Not taking beta-blockers was evaluated on Heart rate-adjusted augmentation index (AIx75) (p=.04). Beta-blocker use in patients with peripheral arterial disease was associated with a lower heart rate-adjusted augmentation index (P=0.04) but higher augmentation and pulse pressures.
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