Key result
Colchicine administered prior to reperfusion significantly preserved sympathetic innervation in the remote myocardial area compared to placebo in a mouse model of acute myocardial infarction.
Why the study?
To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction.
Does colchicine prevent sympathetic denervation in a mouse model of myocardial ischemia-reperfusion?
Does colchicine prevent sympathetic denervation in a mouse model of myocardial ischemia-reperfusion?
Answers are grounded in this paper and cite their sources.
In a mouse model of ischemia-reperfusion, low-dose colchicine prevented sympathetic denervation in the remote myocardium, suggesting a potential mechanism for its protective effects after acute myocardial infarction.
PURPOSE: To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI). MATERIALS & METHODS: Ischemia/Reperfusion was induced in C57BL/6J male mice. Left coronary artery was ligated during 45 min followed by reperfusion. 400 μg/kg of colchicine or the placebo was administrated intraperitoneally 15 min before the reperfusion. RESULTS: Colchicine treatment significantly improved heart rate variability index after AMI. Colchicine prevented sympathetic denervation in the remote area (p = 0.04) but not in the scar area (p = 0.70). CONCLUSION: These results suggest promising protective pathway of colchicine after AMI.
No takes yet. Share an insight, caveat, or question.
Huet et al. (2020) studied Acute myocardial infarction (ischemia-reperfusion injury). Colchicine vs. Placebo was evaluated on Sympathetic innervation in the remote area (TH area/image area %) (p=0.04). Colchicine administered prior to reperfusion significantly preserved sympathetic innervation in the remote myocardial area compared to placebo in a mouse model of acute myocardial infarction.
Synapse has enriched 10 related papers. Consider them for comparative context: