Why the study?
Does nifedipine 20 mg twice daily reduce blood pressure in adult Nigerians with mild-to-moderate essential hypertension?
Does nifedipine 20 mg twice daily reduce blood pressure in adult Nigerians with mild-to-moderate essential hypertension?
Nifedipine monotherapy is highly effective at reducing systolic and diastolic blood pressure in adult black patients with mild-to-moderate essential hypertension.
Nifedipine 20 mg BID substantially lowers BP in adult Nigerians; confirms CCB monotherapy efficacy in black patients with mild-to-moderate hypertension.
Thirty-two adult Nigerians with mild-to-moderate essential hypertension were included in a double-blind placebo-controlled trial matching nifedipine 20 mg twice daily with placebo for 6 weeks. Nifedipine caused very significant reductions of both systolic and diastolic blood pressures in all patients. Blood pressure fell from a mean of 181.3 (SE 3.9)/114.7 (SE 2.4) to 122.8 (SE 1.9)/79.4 (SE 1.6). Mean arterial pressure fell from a mean of 136.75 (SE -2.2) to 94.19 (SE -1.39). Polyuria was a common side effect in six of the 16 patients who received nifedipine. One additional patient developed transient occipital headache. Nifedipine monotherapy would appear to be an effective first-line drug in the management of essential hypertension in adult blacks.
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Fadayomi et al. (1986) studied this question.
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