Key result
Bioinformatics analysis identified 33 common differentially expressed genes, highlighting PRF1 and IL2RB as key hub genes and miR-375 as a potential diagnostic marker for both HFpEF and NAFLD.
Why the study?
Heart failure with preserved ejection fraction and non-alcoholic fatty liver disease are related conditions with an increasing incidence, but the mechanism of their relationship remains undefined.
Population
HFpEF and NAFLD datasets from the Gene Expression Omnibus database
Design
Bioinformatics study
Authors
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PRF1, IL2RB, and miR-375 require prospective validation; leaves open their diagnostic utility in HFpEF with NAFLD.
Bioinformatics analysis reveals shared pathogenetic mechanisms (inflammation and immune infiltration), hub genes (PRF1, IL2RB), a potential biomarker (miR-375), and candidate drugs for HFpEF and NAFLD.
Wang et al. (2022) studied Heart failure with preserved ejection fraction (HFpEF) and non-alcoholic fatty liver disease (NAFLD). HFpEF and NAFLD vs. Healthy controls was evaluated on Differentially expressed genes (DEGs) and hub genes. Bioinformatics analysis identified 33 common differentially expressed genes, highlighting PRF1 and IL2RB as key hub genes and miR-375 as a potential diagnostic marker for both HFpEF and NAFLD.
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