Why the study?
Do PPARgamma ligands increase nitric oxide release in endothelial cells?
Population
Porcine pulmonary artery endothelial cells, human aortic endothelial cells, and human umbilical vein…
Design
Preclinical
Follow-up
up to 24 hours
Authors
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Hypothesis-generating for PPARγ atheroprotection via endothelial NO; leaves open clinical translation and human validation.
Do PPARgamma ligands increase nitric oxide release in endothelial cells?
PPARgamma ligands stimulate nitric oxide release from endothelial cells via a transcriptional mechanism independent of eNOS expression, suggesting a mechanism for their atheroprotective effects.
Calnek et al. (2003) studied this question.
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