Why the study?
Do PPARalpha activators increase eNOS expression and activity in cultured vascular endothelial cells?
Population
Cultured bovine aortic endothelial cells
Design
Preclinical
Follow-up
48 hours
Authors
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May support PPARα-mediated endothelial protection in vitro; leaves open clinical translation in humans.
Do PPARalpha activators increase eNOS expression and activity in cultured vascular endothelial cells?
PPARalpha activators upregulate eNOS expression in vascular endothelial cells by stabilizing eNOS mRNA, providing a molecular mechanism for their cardiovascular protective effects.
Goya et al. (2004) studied this question.
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