Key result
Obesity and its associated metabolic disturbances, including altered adipokine secretion and ectopic fat deposition, have complex direct and indirect effects on multiple organ systems.
Why the study?
Obesity is increasing globally, but the complex interplay between obesity-related metabolic disturbances, multi-organ dysfunction, brain aging, and neurodegenerative diseases remains difficult to fully understand.
This review highlights the complex interplay between obesity-induced metabolic disturbances, altered adipokine profiles, and their systemic effects on multiple organs including the brain.
Answers are grounded in this paper and cite their sources.
May inform holistic obesity management across specialties; extends mechanistic synthesis but leaves causal pathways open for trials.
Obesity is increasing at unprecedented levels globally, and the overall impact of obesity on the various organ systems of the body is only beginning to be fully appreciated. Because of the myriad of direct and indirect effects of obesity causing dysfunction of multiple tissues and organs, it is likely that there will be heterogeneity in the presentation of obesity effects in any given population. Taken together, these realities make it increasingly difficult to understand the complex interplay between obesity effects on different organs, including the brain. The focus of this review is to provide a comprehensive view of metabolic disturbances present in obesity, their direct and indirect effects on the different organ systems of the body, and to discuss the interaction of these effects in the context of brain aging and the development of neurodegenerative diseases.
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Uranga et al. (2019) conducted a review in Obesity and metabolic dysfunction. Obesity was evaluated. Obesity and its associated metabolic disturbances, including altered adipokine secretion and ectopic fat deposition, have complex direct and indirect effects on multiple organ systems.
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