Why the study?
Does intravenous glucagon alter left ventricular performance in patients with severe aortic stenosis?
Does intravenous glucagon alter left ventricular performance in patients with severe aortic stenosis?
Intravenous glucagon increases cardiac output and left ventricular volume in severe aortic stenosis, likely through the Frank-Starling mechanism rather than a direct increase in contractility.
Answers are grounded in this paper and cite their sources.
May support glucagon to raise output in severe AS via preload; leaves open inotropic effects and clinical utility.
The effect of intravenous glucagon (2 or 3 mg) was studied at cardiac catheterization in 3 patients with severe aortic stenosis, using a thermodilution technique to measure left ventricular volume. There was a striking rise in cardiac output (from 4.4 to 6-3 ./min on average) with only a moderate increase in heart rate. Left ventricular end-diastolic pressure rose considerably and there was a conspicuous increase in left ventricular volume. However, mean circumferential shortening rate, an index of contractility, was little affected. As left ventricular systolic pressure rose, there was a considerable increase in wall force, possibly due to the Frank- Starling effect in the dilated left ventricle.
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Hamer et al. (1973) studied this question.
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