January 1, 2000HypertensionOpen Access

Inhibition of Adrenal Cell Aldosterone Synthesis by Endogenous Nitric Oxide Release

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Population

Adrenal zona glomerulosa (ZG) cells

Comparison

Transduction with a recombinant adenovirus… vs Control cells or cells transduced with…

Design

Preclinical

Authors

CHCraig J. HankeUniversity of Wisconsin–Green Bay TOTimothy O’BrienUniversity Hospitals of Cleveland KPKirkwood A. PritchardUniversity of Wisconsin–Milwaukee

Discussion

Member takes

Implication

eNOS gene transfer suppresses aldosterone synthesis; hypothesis-generating for hyperaldosteronism, human translation untested.

Structured PICO

Population

Adrenal zona glomerulosa (ZG) cells

Intervention

Transduction with a recombinant adenovirus encoding the endothelial NOS gene (AdeNOS)

Comparator

Control cells or cells transduced with adenovirus encoding the beta-galactosidase gene (AdbetaGal)

Outcome

Aldosterone synthesis and nitrate/nitrite production after stimulation with angiotensin IIsurrogate

Endogenous nitric oxide production via eNOS gene transfer in adrenal zona glomerulosa cells significantly decreases angiotensin II-stimulated aldosterone synthesis.

Cite This Study

Hanke et al. (2000) studied this question.

synapsesocial.com/papers/6a6f484126770c2b8ddfeacc https://doi.org/10.1161/01.hyp.35.1.324

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Inhibition of Adrenal Cell Aldosterone Synthesis by Endogenous Nitric Oxide Release

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of Adrenal Cell Aldosterone Synthesis by Endogenous Nitric Oxide Release

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider