Key result
Experimental human infection with rhinovirus 39 resulted in rapid generation of new variants over 5 days, with an estimated in vivo mutation frequency of 3.4x10^-4 mutations/nucleotide across the entire open reading frame.
Human rhinoviruses generate new variants rapidly during acute infection with mutations accumulating in specific hot spot regions, informing future vaccine and antiviral design.
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Rapid variant generation in acute rhinovirus infection may inform resistance monitoring; leaves open implications for vaccine design pending clinical validation.
Cordey et al. (2010) studied Experimental human rhinovirus (HRV-39) infection (n=15). Experimental HRV-39 infection vs. In vitro HeLa-OH cell infection was evaluated on Mutation frequency in vivo over the entire open reading frame. Experimental human infection with rhinovirus 39 resulted in rapid generation of new variants over 5 days, with an estimated in vivo mutation frequency of 3.4x10^-4 mutations/nucleotide across the entire open reading frame.
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