Phylogenetic Relationships and Molecular Adaptation Dynamics of Human Rhinoviruses
Population
45 Human rhinovirus (HRV) serotypes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Protein phenotypic analysis may outperform dN/dS for viral selection detection; leaves open its role in rhinovirus research pending validation.
Structured PICO
P
Population
45 Human rhinovirus (HRV) serotypes
I
Intervention
Phylogenetic and evolutionary analysis (recombination and selection tests for individual genes and coding genome)
O
Outcome
Evolutionary history, recombination, and positive selection
Protein phenotypic expression is a more sensitive approach than d(N)/d(S) for detecting positive selection in human rhinoviruses, revealing distinct evolutionary pressures among serotypes.
Cite This Study
Lewis-Rogers et al. (2009) studied this question.