January 1, 2007Virology JournalOpen Access

Genome-wide diversity and selective pressure in the human rhinovirus

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Population

35 fully sequenced human rhinovirus genomes, including 28 newly sequenced diverse reference serotypes, 1…

Design

Preclinical

Authors

AKAmy KistlerChan Zuckerberg Initiative (United States)DWDale R. WebsterGoogle (United States)SRSilvi RouskinHarvard University

Discussion

Member takes

Implication

Hypothesis-generating for HRV evolution; leaves open translation to human vaccine or antiviral strategies.

Structured PICO

Population

35 fully sequenced human rhinovirus (HRV) genomes, including 28 newly sequenced diverse reference serotypes, 1 clinical isolate, and 6 previously sequenced genomes

Intervention

Whole genome sequencing and comparative genomic analysis (phylogenetic, recombination, and selective pressure analysis)

Outcome

Genome-wide genetic diversity, recombination frequency, and selective pressure (dN/dS ratios)

Genomic analysis of 35 human rhinovirus serotypes reveals limited recombination and overall purifying selection, with localized diversifying pressure in capsid proteins driven by immune evasion and in non-structural proteins.

Cite This Study

Kistler et al. (2007) studied this question.

synapsesocial.com/papers/6a71f2892163a0a01bc5dcd7 https://doi.org/10.1186/1743-422x-4-40

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Genome-wide diversity and selective pressure in the human rhinovirus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Genome-wide diversity and selective pressure in the human rhinovirus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider