Key result
In an ex-vivo porcine heart model, rupture of the chordae tendineae immediately caused the tricuspid valve annulus to significantly dilate by approximately 9% in area.
Why the study?
Does chordae tendineae rupture cause immediate dilation of the tricuspid valve annulus in ex-vivo porcine hearts?
Population
8 ex-vivo fresh porcine hearts
Comparison
Rupture of chordae tendineae vs Intact heart
Design
Preclinical
Follow-up
Immediate (during the experiment)
Authors
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May implicate chordal rupture in tricuspid annular dilation; hypothesis-generating and requires in vivo confirmation.
Does chordae tendineae rupture cause immediate dilation of the tricuspid valve annulus in ex-vivo porcine hearts?
Effect estimate: 9% dilation
Absolute Event Rate: 14.4% vs 13.3%
p-value: p=0.01
In an ex-vivo porcine model, the tricuspid valve annulus dilates immediately following chordae tendineae rupture, suggesting early geometric changes that may exacerbate secondary regurgitation.
Khoiy et al. (2018) studied Tricuspid valve chordae rupture (ex-vivo model) (n=8). Chordae rupture vs. Intact heart was evaluated on Tricuspid valve annulus area (9% dilation, p=0.01). In an ex-vivo porcine heart model, rupture of the chordae tendineae immediately caused the tricuspid valve annulus to significantly dilate by approximately 9% in area.
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