Key result
An indirect chemiluminescence immunoassay using a multiepitope recombinant protein was developed to specifically detect FMDV serotype O antibodies in swine, addressing high false-positive rates.
Why the study?
Postvaccination seromonitoring is important for controlling and eradicating foot-and-mouth disease, but many commercial kits present high false-positive rates.
Does ME-CLIA accurately detect antibodies against FMDV serotype O in swine compared to commercial kits?
Does ME-CLIA accurately detect antibodies against FMDV serotype O in swine compared to commercial kits?
This is the authors' abstract. We don't add key points for this paper.
Foot-and-mouth disease virus (FMDV) has led to serious losses in animal husbandry worldwide. Seromonitoring of FMDV postvaccination is important for the control and eradication of foot-and-mouth disease (FMD) in regions and countries where vaccination is widespread. However, many commercial kits present high false-positive rates.
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ME-CLIA is a highly sensitive and specific method for detecting antibodies against FMDV serotype O in swine, suitable for evaluating vaccine efficacy.
Liu et al. (2020) studied this question. An indirect chemiluminescence immunoassay using a multiepitope recombinant protein was developed to specifically detect FMDV serotype O antibodies in swine, addressing high false-positive rates.
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