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March 1, 1989Journal of General VirologyOpen Access

Evidence for At Least Four Antigenic Sites on Type O Foot-and-Mouth Disease Virus Involved in Neutralization; Identification by Single and Multiple Site Monoclonal Antibody-resistant Mutants

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Population

Type O foot-and-mouth disease virus and single/multiple site monoclonal antibody-resistant mutants

Design

Preclinical

Authors

DMD. McCahonThe Pirbright InstituteJCJ. R. CrowtherUNSW SydneyGBGraham J. BelshamStatens Serum Institut

Discussion

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Implication

Suggests further neutralization mechanisms on type O FMDV; leaves open refinement of multi-epitope vaccines for cattle.

Structured PICO

P
Population
Type O foot-and-mouth disease virus and single/multiple site monoclonal antibody-resistant mutants
I
Intervention
Neutralizing monoclonal antibodies
O
Outcome
Identification of antigenic sites involved in virus neutralizationsurrogate

The study identifies at least four distinct antigenic sites on the type O foot-and-mouth disease virus involved in neutralization, providing insights into viral immune evasion.

Cite This Study

McCahon et al. (1989) studied this question.

synapsesocial.com/papers/6a6f576d75498292b708bc80https://doi.org/10.1099/0022-1317-70-3-639
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neutralization of Foot-and-Mouth Disease Virus Can Be Mediated Through Any of at least Three Separate Antigenic Sites1987 · 175 citations
  2. 2The Main Antigenic Determinant Detected by Neutralizing Monoclonal Antibodies on the Intact Foot-and-Mouth Disease Virus Particle is Absent from Isolated VP11983 · 39 citations
  3. 3Localization of a Neutralization Epitope of Foot-and-Mouth Disease Virus Using Neutralizing Monoclonal Antibodies1984 · 14 citations
  4. 4Mutations conferring resistance to neutralization with monoclonal antibodies in type 1 poliovirus can be located outside or inside the antibody-binding site1986 · 121 citations
  5. 5Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 141986 · 304 citations