August 1, 1993Journal of General Virology

Identification of a fifth neutralizable site on type O foot-and-mouth disease virus following characterization of single and quintuple monoclonal antibody escape mutants

View Full Paper

Ask AI

Bookmark

Population

Foot-and-mouth disease virus type O1Caseros and type O1Kaufbeuren (parental, single C3, and quintuple mutants)

Design

Preclinical

Authors

JCJ. R. CrowtherUNSW Sydney SFSandra Estrazulas FariasUniversidade Federal do Rio Grande do Sul WCWilliam C. CarpenterInstitute of Electrical and Electronics Engineers

Discussion

Member takes

Implication

Highlights potential FMDV immune escape; leaves open whether this informs livestock vaccine design.

Structured PICO

Population

Foot-and-mouth disease virus type O1Caseros and type O1Kaufbeuren (parental, single C3, and quintuple mutants)

Intervention

Monoclonal antibody (C3) and characterization of escape mutants

Outcome

Identification and characterization of a fifth neutralizable sitesurrogate

The identification of a fifth neutralizable site on the foot-and-mouth disease virus provides insights into the virus's antigenic structure and immune evasion mechanisms.

Cite This Study

Crowther et al. (1993) studied this question.

synapsesocial.com/papers/6a8af5d3a42d46e0ffcaa480 https://doi.org/10.1099/0022-1317-74-8-1547

View Full Paper

Ask AI

Bookmark

Identification of a fifth neutralizable site on type O foot-and-mouth disease virus following characterization of single and quintuple monoclonal antibody escape mutants

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of a fifth neutralizable site on type O foot-and-mouth disease virus following characterization of single and quintuple monoclonal antibody escape mutants

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider