Key result
A lateral-flow assay for foot-and-mouth disease virus demonstrated 87.3% sensitivity and 98.8% specificity, comparable to Ag-ELISA, supporting its use for rapid field detection.
Absolute Event Rate: 87.3% vs 87.7%
The LFA using MAb 70-17 provides a rapid, supportive method for detecting FMDV at the site of suspected outbreaks with comparable sensitivity to Ag-ELISA.
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May enable faster field confirmation during FMD outbreaks; leaves open need for multi-strain prospective validation.
Oem et al. (2009) studied Foot-and-mouth disease (n=804). Lateral-flow assay (LFA) based on MAb 70-17 vs. Antigen enzyme-linked immunosorbent assay (Ag-ELISA) was evaluated on Diagnostic sensitivity for FMDV types O, A, C, and Asia 1. A lateral-flow assay for foot-and-mouth disease virus demonstrated 87.3% sensitivity and 98.8% specificity, comparable to Ag-ELISA, supporting its use for rapid field detection.
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