Key result
The LFI strip test detected FMDV SAT 2 with 64% diagnostic sensitivity and 100% specificity, compared to 32% sensitivity and 98.8% specificity for the DAS ELISA.
Why the study?
Foot-and-mouth disease (FMD) outbreaks due to serotype SAT 2 affect many African countries, and developing a rapid, easily performed diagnostic test is critical for outbreak control and containment.
Absolute Event Rate: 64% vs 32%
A newly developed lateral flow strip test provides rapid and sensitive on-site detection of FMDV SAT 2, outperforming standard DAS ELISA.
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LFI may enable faster field detection of FMDV SAT 2; leaves open prospective validation before any practice change.
Yang et al. (2018) studied Foot-and-mouth disease virus (FMDV) SAT 2 (n=137). Lateral flow immunochromatographic (LFI) strip test vs. Double-antibody sandwich (DAS) ELISA was evaluated on Diagnostic sensitivity in positive tissue samples. The LFI strip test detected FMDV SAT 2 with 64% diagnostic sensitivity and 100% specificity, compared to 32% sensitivity and 98.8% specificity for the DAS ELISA.
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