Population
Foot-and-mouth disease virus (FMDV) capsids expressed in a vaccinia virus expression system
Comparison
Mutation of His-142 of protein 1C to Arg, Phe… vs Wild-type FMDV capsids
Design
Preclinical
Authors
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May inform FMDV vaccine engineering; leaves open translation to in vivo stability or efficacy.
Mutation of His-142 of protein 1C confirms the role of a histidine-alpha-helix charge-dipole interaction in the acid-induced disassembly of FMDV capsids.
Ellard et al. (1999) studied this question.
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