What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Foot-and-mouth disease (n=13). Intervention: Laboratory capacity for FMD diagnosis. Primary outcome: Laboratory capacity, diagnostic techniques, and quality management systems.

What question did this study set out to answer?

To assess the diagnostic capacity of national reference laboratories in Eastern Africa to support progressive foot-and-mouth disease control initiatives.

January 24, 2013BMC Veterinary ResearchOpen Access

Laboratory capacity for diagnosis of foot-and-mouth disease in Eastern Africa: implications for the progressive control pathway

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Key result

FMD diagnostic capacity in Eastern Africa remains inadequate, with only two countries having biosecurity level 3 laboratories and none achieving accreditation for FMD diagnosis.

Population

14 National Reference Laboratories mandated to diagnose foot-and-mouth disease in 12 Eastern Africa member…

Design

Cross-sectional

Authors

ANAlice NamatovuFood and Agriculture Organization of the United Nations SWSabenzia Nabalayo WekesaMinistry of Agriculture Livestock and Fisheries KTKirsten TjørnehøjStatens Serum Institut

Discussion

Member takes

Overview

Limits FMD control in Eastern Africa; leaves open optimal accreditation and regional lab network strategies.

Key Points

To assess the diagnostic capacity of national reference laboratories in Eastern Africa to support progressive foot-and-mouth disease control initiatives.
Surveyed 14 national reference laboratories within the Eastern Africa Region Laboratory Network using a semi-structured questionnaire.
Analyzed retrospective outbreak and diagnostic data from World Reference Laboratory annual reports and GenBank records spanning 2006 to 2010.
Achieved a 93% response rate (13/14 laboratories), with 12 of 13 countries reporting at least one outbreak between 2006 and 2010, and 12 of 13 remaining below stage 3 of the control pathway.
Only 2 of 13 laboratories possessed biosecurity level 3 containment, and only 3 of 13 consistently determined viral serotypes across all reported outbreaks.
Most laboratories relied on serology (12/13) and antigen ELISA (7/13), while only 3 utilized molecular tests, 4 (31%) engaged in proficiency testing, and none achieved diagnostic accreditation.

Study Design

Type

Cross-Sectional (n=13)

Multicenter

Yes

Structured PICO

Population

13 National Reference Laboratories in Eastern Africa were surveyed to assess their laboratory capacity for diagnosing foot-and-mouth disease between 2006 and 2010.

Outcome

Laboratory capacity for diagnosis of foot-and-mouth disease (FMD)

FMD diagnostic capacity in Eastern Africa is inadequate, highlighting the need for improved laboratory infrastructure, quality management systems, and regional reference laboratories to support disease control.

Limitations

Self-assessment of PCP-FMD stages by countries/regions
Incomplete response rate (13 out of 14 NRLs)
Reliance on retrospective data for sample submissions and circulating serotypes

Cite This Study

Namatovu et al. (2013) conducted a cross-sectional in Foot-and-mouth disease (n=13). Laboratory capacity for FMD diagnosis was evaluated on Laboratory capacity, diagnostic techniques, and quality management systems. FMD diagnostic capacity in Eastern Africa remains inadequate, with only two countries having biosecurity level 3 laboratories and none achieving accreditation for FMD diagnosis.

synapsesocial.com/papers/6a6f5901e5469ee92be05523 https://doi.org/10.1186/1746-6148-9-19

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January 24, 2013BMC Veterinary ResearchOpen Access

Laboratory capacity for diagnosis of foot-and-mouth disease in Eastern Africa: implications for the progressive control pathway

View Full Paper

Ask AI

Bookmark

Key result

FMD diagnostic capacity in Eastern Africa remains inadequate, with only two countries having biosecurity level 3 laboratories and none achieving accreditation for FMD diagnosis.

Population

14 National Reference Laboratories mandated to diagnose foot-and-mouth disease in 12 Eastern Africa member…

Design

Cross-sectional

Authors

ANAlice NamatovuFood and Agriculture Organization of the United Nations SWSabenzia Nabalayo WekesaMinistry of Agriculture Livestock and Fisheries KTKirsten TjørnehøjStatens Serum Institut

Discussion

Member takes

Overview

Limits FMD control in Eastern Africa; leaves open optimal accreditation and regional lab network strategies.

Key Points

To assess the diagnostic capacity of national reference laboratories in Eastern Africa to support progressive foot-and-mouth disease control initiatives.
Surveyed 14 national reference laboratories within the Eastern Africa Region Laboratory Network using a semi-structured questionnaire.
Analyzed retrospective outbreak and diagnostic data from World Reference Laboratory annual reports and GenBank records spanning 2006 to 2010.
Achieved a 93% response rate (13/14 laboratories), with 12 of 13 countries reporting at least one outbreak between 2006 and 2010, and 12 of 13 remaining below stage 3 of the control pathway.
Only 2 of 13 laboratories possessed biosecurity level 3 containment, and only 3 of 13 consistently determined viral serotypes across all reported outbreaks.
Most laboratories relied on serology (12/13) and antigen ELISA (7/13), while only 3 utilized molecular tests, 4 (31%) engaged in proficiency testing, and none achieved diagnostic accreditation.

Study Design

Type

Cross-Sectional (n=13)

Multicenter

Yes

Structured PICO

Population

13 National Reference Laboratories in Eastern Africa were surveyed to assess their laboratory capacity for diagnosing foot-and-mouth disease between 2006 and 2010.

Outcome

Laboratory capacity for diagnosis of foot-and-mouth disease (FMD)

Limitations

Self-assessment of PCP-FMD stages by countries/regions
Incomplete response rate (13 out of 14 NRLs)
Reliance on retrospective data for sample submissions and circulating serotypes

Cite This Study

synapsesocial.com/papers/6a6f5901e5469ee92be05523 https://doi.org/10.1186/1746-6148-9-19

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